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Fig. 2 | Parasites & Vectors

Fig. 2

From: Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

Fig. 2

Dynamics of aneuploidy of L. infantum after in vitro adaptation to TPT. a Heatmap representation of log2-transformed normalized TPT-resistant/WT read ratio for all 36 chromosomes in the three independent L. infantum TPT-resistant lines selected at 16 × EC50. Chromosomes were divided into non-overlapping 5 kb genomic windows, and the median L. infantum TPT-resistant/WT read ratios for each chromosome were normalized according to the total number of reads followed by log2 transformation. b Log2-transformed 16 × TPT-resistant mutants/WT reads ratios for non-overlapping 5 kb genomic windows on chromosome 12. c Log2-transformed 16 × TPT-resistant mutants/WT reads ratios for non-overlapping 5 kb genomic windows on chromosome 32

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Parasites & Vectors

ISSN: 1756-3305

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