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Fig. 3 | Parasites & Vectors

Fig. 3

From: Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

Fig. 3

Impact of overexpression of the leishmanial top1BWT gene, as well as three mutated versions, on the TPT sensitivity profile of L. infantum. EC50 values were calculated from concentration–response curves performed in triplicate after nonlinear fitting. Data are the mean ± SEM of three biological replicates. Differences were statistically evaluated by unpaired two-tailed t-test (***P ≤ 0.001, ****P ≤ 0.0001)

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Parasites & Vectors

ISSN: 1756-3305

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