Table 5 Interrogation of gorge geometry by responses to tacrine and tacrine dimers of varying tether lengths

Tacrine

585 (488–701)

3872 {6.6} (3267–4646)

1,911 {3.3} (1379–2649)

2049 {3.5} (1463–2870)

bis(2)-tacrine

226 (192–267)

2138 {9.5} (1594–2867)

172 {0.76} (141–210)

8,842 {39} (6664–11,730)

bis(3)-tacrine

29 (25–33)

45 {1.6} (34–59)

13 {0.45} (11–16)

444 {15} (323–609)

bis(4)-tacrine

52 (44–60)

96 {1.8} (64–154)

25 {0.48} (21–30)

618 {12} (575–663)

bis(5)-tacrine

13 (12–15)

55 {4.2} (46–65)

2.3 {0.18} (1.7–3.2)

324 {25} (250–418)

bis(6)-tacrine

9.2 (7.5–11)

12 {1.3} (8.8–17)

2.7 {0.29} (2.2–3.4)

102 {11} (85–121)

bis(7)-tacrine

4 (3–5.3)

5.3 {1.3} (4.6–6)

2.9 {0.73} (2.2–3.8)

37 {9.3} (31–44)

bis(8)-tacrine

0.6 (0.5–0.7)

2.7 {4.5} (2.3–3.2)

0.3 {0.50} (0.2–0.4)

11 {18} (9.7–13)

bis(9)-tacrine

4.8 (3.2–7.2)

3.4 {0.7} (2.9–3.8)

1.8 {0.38} (1.5–2.1)

24 {5} (20–29)

bis(12)-tacrine

9.3 (8.2–10)

35 {3.8} (28–42)

6.6 {0.71} (5.5–8)

121 {13} (105–139)