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Table 1 Lethal concentrations of fluralaner in unfed larvae of Rhipicephalus microplus populations under laboratory conditions (27 ± 1 °C and relative humidity > 80 ± 5%)

From: Acaricidal efficacy of fluralaner against Rhipicephalus microplus ticks under laboratory and field conditions in Brazil

Populationa

City and State

LC50b

Confidence interval

RR50c

LC99b

Confidence interval

 Mortality at the two concentrations used for LC50 calculations 

1.56 µg/mL

3.12 µg/mL

POA

Porto Alegre—RS

0.208

0.203–0.213

 

0.777

0.720–0.846

100

100

GYN

Goiânia—GO

0.167*

0.162–0.173

0.803

0.812

0.759–0.873

100

100

1

Padre Paraíso—MG

0.156*

0.150–0.164

0.750

1.530*

1.355–1.747

99.9

100

2

Iturama—MG

0.244

0.234–0.253

1.173

1.650*

1.515–1.810

100

100

3

Planaltina—DF

0.272*

0.265–0.281

1.308

1.271*

1.192–1.362

100

100

4

Nova Friburgo—RJ

0.186*

0.180–0.191

0.894

0.736

0.684–0.799

100

100

5

Bela Vista de Goiás—GO

0.183*

0.176–0.191

0.880

1.216*

1.103–1.353

100

100

6

São Miguel do Passa Quatro—GO

0.287*

0.281–0.293

1.380

0.841

0.795–0.893

100

100

7

Uruçuca—BA

0.411*

0.400–0.424

1.976

1.547*

1.438–1.674

100

100

8

Rio Espera—MG

0.210

0.205–0.215

1.010

0.671

0.630–0.720

100

100

9

Pará de Minas—MG

0.198

0.194–0.203

0.952

0.753

0.707–0.807

100

100

10

Piracanjuba—GO

0.415*

0.402–0.428

1.995

2.352*

2.170–2.566

100

100

11

Ingaí—MG

0.292*

0.284–0.300

1.404

1.070*

0.992–1.163

100

100

12

Esmeraldas—MG

0.313*

0.302–0.324

1.505

2.523*

2.295–2.796

100

100

13

Bonfinópolis—MG

0.375*

0.361–0.390

1.803

3.371*

3.043–3.766

100

100

14

Anápolis—GO

0.144*

0.140–0.148

0.692

0.567*

0.532–0.608

100

100

15

Jataí—GO

0.216

0.207–0.225

1.038

2.197*

1.959–2.490

100

100

16

São João da Boa Vista—SP

0.481*

0.472–0.491

2.313

2.060*

1.517–1.828

100

100

  

LC99 considering mortality data from all populations

  

1.581

1.546–1.617

  
  1. aPOA is the strain susceptible to acaricides. GYN is the strain resistant to synthetic pyrethroids, formamidines, organophosphate and phenylpyrazoles. Populations 1—16 were obtained from samples of R. microplus collected on farms in different regions of Brazil
  2. bLC50 and LC99 are the lethal concentrations (LC; µg/mL = ppm) producing 50% and 99% mortality, respectively, among the tested study populations. Asterisks indicate significantly different values of LC50 and LC99 relative to the POA strain
  3. cRR50 is the resistance ratio, calculated from the LC50
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Parasites & Vectors

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