Efficacy of an oral combination of afoxolaner and milbemycin oxime for the prevention of transmission of Babesia canis by Dermacentor reticulatus ticks to dogs

Table 1 Animal characteristics and study outline

Groups		Animal characteristics at inclusion (on Day −2)			IVP treatment	D. reticulatus		Daily rectal temperatures¹	PCR and IFA analyses²
	n	Sex	Age (months)	Body weight (kg)	IVP treatment	Infestation(s)	Removal(s)	Daily rectal temperatures¹	PCR and IFA analyses²
Control 1	8	4 m, 4 f	19–88	12.1–20.0	NA	Day 1	Day 7	Days 1–56	Days 21 and 28
Control 2	8	3 m, 5 f	31–88	12.9–23.4	NA	Day 28	Day 34	Days 1–56	Days 42 and 56
IVP	8	4 m, 4 f	28–82	14.2–23.8	Day 0	Days 1 and 28	Days 7 and 34	Days 1–56	Days 21, 28, 42, and 56

Animals were examined for clinical signs once a day until day 6 and twice daily from day 7 to day 56
¹ Whenever the rectal temperature exceeded 39.5 °C, and/or babesiosis was suspected on the basis of clinical signs, blood was collected for blood smear microscopical examination and PCR analysis. A dog with a positive blood smear was rescue treated
² A dog was removed from the study once a PCR and an IFA analysis were positive

ISSN: 1756-3305