Safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) in homozygous MDR1-mutant collie dogs

Table 1 Study design information

Treatment group	Treatment	Target MRTD (mg/kg)	Dogs^a
1	0× (Vehicle Control)	0	8
2	1×	Lotilaner = 40 Moxidectin = 0.04 Praziquantel = 10 Pyrantel = 10	8
3	2×	Lotilaner = 80 Moxidectin = 0.08 Praziquantel = 20 Pyrantel = 20	8
4	5×	Lotilaner = 200 Moxidectin = 0.20 Praziquantel = 50 Pyrantel = 50	8

^a Dogs were divided into two equal cohorts with four dogs/cohort/treatment group

ISSN: 1756-3305