Table 2 Signs of avermectin associated toxicity and scoring criteria
Clinical sign* | Score | Description of criteria |
|---|---|---|
Depression | 0: normal | Normal response to stimuli |
1: mild | Lethargy. Response to stimuli subdued. Appears confused | |
2: moderate | Semi-responsive, stupor. Will respond only to persistent stimuli | |
3: severe | Recumbent, weak, nonresponsive. Little or no response to stimulus, including deep pain (toe pinch). Unaware of surroundings | |
Ataxia | 0: normal | Usual gait and posture |
1: mild | Detectable incoordination but moves with little difficulty | |
2: moderate | Able to stand but moves with difficulty because of incoordination/ataxia | |
3: severe | Unable to remain standing without support or unable to rise from recumbency because of incoordination/ataxia | |
Mydriasis** | 0: normal | Usual pupillary response |
1: mild | Partial mydriasis, responds to light | |
3: severe | Complete mydriasis, does not respond to light | |
Salivation/drooling/vomiting | 0: normal | Salivation/drooling not apparent |
1: mild | Salivation/drooling minimal or 1 time vomit | |
2: moderate | Consistent/moderate salivation/drooling or two times vomit | |
3: severe | Excessive salivation/drooling or greater than two times vomit | |
Muscle tremor | 0: normal | None, no apparent muscle tremors |
1: mild | Localized/intermittent muscle tremors noted | |
2: moderate | Moderate whole body muscle tremors | |
3: severe | Marked whole body muscle tremors |